Stabilization of Hot-Melt Extrusion Formulations Containing Solid Solutions Using Polymer Blends

In this study, researchers worked on improving the stability of a medication called clotrimazole, commonly used in treating fungal infections. They used a technique called hot-melt extrusion, blending two types of polymers – hydroxypropyl cellulose and poly(ethylene oxide) – to create films that carry the drug. The films were thoroughly tested for their physical and chemical properties, including how they absorb moisture, stick to biological surfaces, and how flexible they are. The goal was to find the perfect mix that ensures the drug is released effectively, remains stable, and has good adhesive qualities. This research is a significant step towards developing better drug delivery systems, enhancing both the effectiveness and user experience of the medication.

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Joshua U. Otaigbe